Most Recent Articles: Epigenetics & Chromatin Most Recent Articles: Epigenetics & Chromatin
- FOSL1 is a key regulator of a super-enhancer driving TCOF1 expression in triple-negative breast cancerpor Qingling He, Jianyang Hu, Hao Huang, Tan Wu, Wenxiu Li, Saravanan Ramakrishnan, Yilin Pan, Kui Ming Chan, Liang Zhang, Mengsu Yang, Xin Wang and Y. Rebecca Chin on noviembre 10, 2024 at 12:00 am
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with an unmet clinical need, but its epigenetic regulation remains largely undefined. By performing multiomic profiling, we recent...
- H3.3K122A results in a neomorphic phenotype in mouse embryonic stem cellspor Benjamin J. Patty, Cailin Jordan, Santana M. Lardo, Kris Troy and Sarah J. Hainer on noviembre 1, 2024 at 12:00 am
Canonical histone H3 and histone variant H3.3 are posttranslationally modified with the genomic distribution of these marks denoting different features and these modifications may influence transcription. Whil...
- Chromatin structure and 3D architecture define the differential functions of PU.1 regulatory elements in blood cell lineagespor Kevin Qiu, Duc C. Vu, Leran Wang, Nicholas N. Nguyen, Anna K. Bookstaver, Katia Sol-Church, Hui Li, Thang N. Dinh, Adam N. Goldfarb, Daniel G. Tenen and Bon Q. Trinh on noviembre 1, 2024 at 12:00 am
The precise spatiotemporal expression of the hematopoietic ETS transcription factor PU.1, a key determinant of hematopoietic cell fates, is tightly regulated at the chromatin level. However, how chromatin sign...
- Epigenetic frontiers: miRNAs, long non-coding RNAs and nanomaterials are pioneering to cancer therapypor Rajkumar Prabhakaran, Rajkumar Thamarai, Sivabalan Sivasamy, Sivanesan Dhandayuthapani, Jyoti Batra, Chinnaperumal Kamaraj, Krishnasamy Karthik, Mohd Asif Shah and Saurav Mallik on octubre 16, 2024 at 12:00 am
Cancer has arisen from both genetic mutations and epigenetic changes, making epigenetics a crucial area of research for innovative cancer prevention and treatment strategies. This dual perspective has propelle...
- Methylation patterns at the adjacent CpG sites within enhancers are a part of cell identitypor Olga Taryma-Leśniak, Jan Bińkowski, Patrycja Kamila Przybylowicz, Katarzyna Ewa Sokolowska, Konrad Borowski and Tomasz Kazimierz Wojdacz on octubre 10, 2024 at 12:00 am
It is generally accepted that methylation status of CpG sites spaced up to 50 bp apart is correlated, and accumulation of locally disordered methylation at adjacent CpG sites is involved in neoplastic transfor...