Most Recent Articles: Fluids and Barriers of the CNS Most Recent Articles: Fluids and Barriers of the CNS
- Mutated LRRK2 induces a reactive phenotype and alters migration in human iPSC-derived pericyte-like cellspor Sanni Peltonen, Tuuli-Maria Sonninen, Jonna Niskanen, Jari Koistinaho, Marika Ruponen and Šárka Lehtonen on noviembre 18, 2024 at 12:00 am
Pericytes play a crucial role in controlling inflammation and vascular functions in the central nervous system, which are disrupted in Parkinson’s disease (PD). Still, there is a lack of studies on the impact ...
- C1-inhibitor to prevent intracerebral hemorrhage-related secondary brain injurypor Kevin Akeret, Bart R. Thomson, Subhajit Ghosh, Marc Nolte, Urs Fischer, Rok Humar, Luca Regli, Dominik J. Schaer, Michael Hugelshofer and Raphael M. Buzzi on noviembre 15, 2024 at 12:00 am
Preclinical studies indicate that the systemic application of C1-inhibitor, clinically used to treat hereditary angioedema, reduces secondary brain injury after ischemic stroke. This study assessed the effect ...
- Exploring dysfunctional barrier phenotypes associated with glaucoma using a human pluripotent stem cell-based model of the neurovascular unitpor Sailee S. Lavekar, Jason M. Hughes, Cátia Gomes, Kang-Chieh Huang, Jade Harkin, Scott G. Canfield and Jason S. Meyer on noviembre 14, 2024 at 12:00 am
Glaucoma is a neurodegenerative disease that results in the degeneration of retinal ganglion cells (RGCs) and subsequent loss of vision. While RGCs are the primary cell type affected in glaucoma, neighboring c...
- Blood-brain barrier permeability increases with the differentiation of glioblastoma cells in vitropor Sabrina Digiovanni, Martina Lorenzati, Olga Teresa Bianciotto, Martina Godel, Simona Fontana, Muhlis Akman, Costanzo Costamagna, Pierre-Olivier Couraud, Annalisa Buffo, Joanna Kopecka, Chiara Riganti and Iris Chiara Salaroglio on noviembre 1, 2024 at 12:00 am
Glioblastoma multiforme (GBM) is an aggressive tumor, difficult to treat pharmacologically because of the blood-brain barrier (BBB), which is rich in ATP-binding cassette (ABC) transporters and tight junction ...
- Phase-contrast MRI analysis of cerebral blood and CSF flow dynamic interactionspor Kimi Piedad Owashi, Pan Liu, Serge Metanbou, Cyrille Capel and Olivier Balédent on octubre 28, 2024 at 12:00 am
Following the Monro-Kellie doctrine, the Cerebral Blood Volume Changes (CB_VC) should be mirrored by the Cerebrospinal Fluid Volume Changes (CSF_VC) at the spinal canal. Cervical level is often chosen to estim...